What is Biopharmaceutical?

Published: 16th February 2010
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Medical drugs produced using biotechnology, called as Biopharmaceuticals. These are mixture of proteins (which includes anti-bodies), nucleic acids (DNA, RNA or antisense oligonucleotides) used for diagnostics purposes in living organisms.

A biotechnology corporation known as Genentech Inc. first developed the product. Nevertheless, it was licensed to a global pharmaceutical company called Eli Lilly and Company, under which the manufacturing and marketing took place in 1982.

Biopharmaceutical classified as Blood factors, Interferons, Vaccines, Monoclonal antibodies, Haematopoietic growth factors, Hormones and Thrombolytic agents..

Biopharmaceuticals are used for treatment of numerous ailments like anemia, leukemia, rheumatoid arthritis, neutropenia, Gaucher's disease, multiple sclerosis, etc.

The drugs are very complicated and takes time. It takes a number of years only to identify the sanative protein, gene sequence and validation process for creating of molecules applying biotechnology. However, progress in biotechnology has rendered a cost-effective way for production of protein-based drugs in large quantities, through PROTEIN MANUFACTURING techniques.

The fusion of certain white blood cells with tumor cells is called Hybridomas. This fusion causes infinite copy for application in the production of certain protein-based drugs known as monoclonal antibodies, which are very impressive in treating cancers and other disorders.

RDNA or genetic engineering, has let the gene that allows for the necessitate protein and need to be transferred from one living being to another, so that, great quantity of drugs can be made. In the process, the transformed host cell that contains the required gene are developed in controlled conditions in large stainless-steel tanks. The cells are then aroused to make the required proteins by certain conditions like maintaining a desirable balance of acidity, temperature and oxygen among other entities. After production, the proteins are then tested very hard in every place of purification, before making active products.

Like all things having their advantages and disadvantages, protein manufacturing has also its very own advantages and disadvantages.

Different ingredients are used to produce high protein. For example, 50 lbs of yeast can create 125 tons of proteins in a day.

Protein is quickly developed wit bacteria.

Harvesting bacterial cells are very costly and difficult.

Nucleic acid can be fatal for human beings. Level of nucleic acid can be decreased through additional processing step, and thus rising the cost of manufacturing.

For more details regarding API manufacturing check out KBI Biopharma online; and also see SEO services group ClickResponse.

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